Drug-induced lupus
In drug-induced lupus not all the typical features of systemic lupus erythematosus are seen, with renal and nervous system involvement being unusual. It usually resolves on stopping the drug.
Features
Most common causes
Less common causes
Features
- arthralgia
- myalgia
- skin (e.g. malar rash) and pulmonary involvement (e.g. pleurisy) are common
- ANA positive in 100%, dsDNA negative
- anti-histone antibodies are found in 80-90%
- anti-Ro, anti-Smith positive in around 5%
 | |
| © Image used on license from DermNet NZ | |
A woman with drug-induced lupus
Most common causes
- procainamide
- hydralazine
Less common causes
- isoniazid
- minocycline
- phenytoin