MRCEM Notes

Drug-induced impaired glucose tolerance

Drugs which are known to cause impaired glucose tolerance include:
  • thiazides, furosemide (less common)
  • steroids
  • tacrolimus, ciclosporin
  • interferon-alpha
  • nicotinic acid
  • atypical antipsychotics e.g. olanzapine

Beta-blockers cause a slight impairment of glucose tolerance. They should also be used with caution in diabetics as they can interfere with the metabolic and autonomic responses to hypoglycaemia
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