Sulfonylureas
Sulfonylureas are oral hypoglycaemic drugs used in the management of type 2 diabetes mellitus. They work by increasing pancreatic insulin secretion and hence are only effective if functional B-cells are present. On a molecular level they bind to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells.
Common adverse effects
Rarer adverse effects
Sulfonylureas should be avoided in breast feeding and pregnancy
Common adverse effects
- hypoglycaemic episodes (more common with long acting preparations such as chlorpropamide)
- weight gain
Rarer adverse effects
- syndrome of inappropriate ADH secretion
- bone marrow suppression
- liver damage (cholestatic)
- peripheral neuropathy
Sulfonylureas should be avoided in breast feeding and pregnancy