MRCEM Notes

Multiple sclerosis: features

Patient's with multiple sclerosis (MS) may present with non-specific features, for example around 75% of patients have significant lethargy.

Visual
  • optic neuritis: common presenting feature
  • optic atrophy
  • Uhthoff's phenomenon: worsening of vision following rise in body temperature
  • internuclear ophthalmoplegia

Sensory
  • pins/needles
  • numbness
  • trigeminal neuralgia
  • Lhermitte's syndrome: paraesthesiae in limbs on neck flexion

Motor
  • spastic weakness: most commonly seen in the legs

Cerebellar
  • ataxia: more often seen during an acute relapse than as a presenting symptom
  • tremor

Others
  • urinary incontinence
  • sexual dysfunction
  • intellectual deterioration
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