Lung cancer: paraneoplastic features
Small cell
Squamous cell
Adenocarcinoma
- ADH
- ACTH - not typical, hypertension, hyperglycaemia, hypokalaemia, alkalosis and muscle weakness are more common than buffalo hump etc
- Lambert-Eaton syndrome
Squamous cell
- parathyroid hormone-related protein (PTH-rp) secretion causing hypercalcaemia
- clubbing
- hypertrophic pulmonary osteoarthropathy (HPOA)
- hyperthyroidism due to ectopic TSH
Adenocarcinoma
- gynaecomastia
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Hypertrophic pulmonary osteoarthropathy is a proliferative periostisis involving that typically involves the long bones. It is often painful.