MRCEM Notes

Hyperlipidaemia: xanthomata

Characteristic xanthomata seen in hyperlipidaemia:

Palmar xanthoma
  • remnant hyperlipidaemia
  • may less commonly be seen in familial hypercholesterolaemia

Eruptive xanthoma are due to high triglyceride levels and present as multiple red/yellow vesicles on the extensor surfaces (e.g. elbows, knees)

Causes of eruptive xanthoma
  • familial hypertriglyceridaemia
  • lipoprotein lipase deficiency

Tendon xanthoma, tuberous xanthoma, xanthelasma
  • familial hypercholesterolaemia
  • remnant hyperlipidaemia

Xanthelasma are also seen without lipid abnormalities

Management of xanthelasma, options include:
  • surgical excision
  • topical trichloroacetic acid
  • laser therapy
  • electrodesiccation
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