MRCEM Notes

Hepatitis E

Overview
  • RNA hepevirus
  • spread by the faecal-oral route
  • incubation period: 3-8 weeks
  • common in Central and South-East Asia, North and West Africa, and in Mexico
  • causes a similar disease to hepatitis A, but carries a significant mortality (about 20%) during pregnancy
  • does not cause chronic disease or an increased risk of hepatocellular cancer
  • a vaccine is currently in development*, but is not yet in widespread use

*New England Journal of Medicine 356:895, 2007
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