MRCEM Notes

HIV: opportunistic infections and other disorders

The table below shows the infections and other disorders that may be encountered by patients with HIV according to the CD4 count.

CD4 count 200 - 500 cells/mm³


DisorderNotes
Oral thrushSecondary to Candida albicans
ShinglesSecondary to herpes zoster
Hairy leukoplakiaSecondary to EBV
Kaposi sarcomaSecondary to HHV-8

CD4 count 100 - 200 cells/mm³

DisorderNotes
CryptosporidiosisWhilst patients with a CD4 count of 200-500 may develop cryptosporidiosis the disease is usually self-limiting and similar to that in immunocompetent hosts
Cerebral toxoplasmosis
Progressive multifocal leukoencephalopathySecondary to the JC virus
Pneumocystis jirovecii pneumonia
HIV dementia

CD4 count 50 - 100 cells/mm³

DisorderNotes
AspergillosisSecondary to Aspergillus fumigatus
Oesophageal candidiasisSecondary to Candida albicans
Cryptococcal meningitis
Primary CNS lymphomaSecondary to EBV

CD4 count < 50 cells/mm³

DisorderNotes
Cytomegalovirus retinitisAffects around 30-40% of patients with CD4 < 50 cells/mm³
Mycobacterium avium-intracellulare infection
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