Cephalosporins
Cephalosporins are a type of β-lactam antibiotic which are bactericidal. They are less susceptible to penicillinases than penicillins.
β-lactam antibiotics work by disrupting the synthesis of bacterial cell walls, by inhibiting peptidoglycan cross-linking.
Mechanism of resistance
β-lactam antibiotics work by disrupting the synthesis of bacterial cell walls, by inhibiting peptidoglycan cross-linking.
Mechanism of resistance
- Changes to penicillin-binding-proteins (PBPs), which are types of transpeptidases (enzymes produced by bacteria that cross-links peptidoglycan chains to form rigid cell walls)