MRCEM Notes

Vitamin D

Vitamin D is a fat soluble vitamin that plays a key role in calcium and phosphate metabolism.

Sources
  • vitamin D2 (ergocalciferol): plants
  • vitamin D3 (cholecalciferol): dairy products, can be synthesised by the skin from sunlight

Functions
  • increases plasma calcium and plasma phosphate
  • increases renal tubular reabsorption and gut absorption of calcium
  • increases osteoclastic activity
  • increases renal phosphate reabsorption

Consequences of vitamin D deficiency:
  • rickets: seen in children
  • osteomalacia: seen in adults
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