Tetracyclines

Tetracyclines are a class of antibiotics which are commonly used in clinical practice.

Examples

• doxycycline
• tetracycline

Mechanism of action

• protein synthesis inhibitors
• binds to 30S subunit blocking binding of aminoacyl-tRNA

Mechanism of resistance

• increased efflux of the bacteria by plasmid-encoded transport pumps, ribosomal protection

Indications

• acne vulgaris
• Lyme disease
• Chlamydia

-Mycoplasma pneumoniae

Adverse effects

• discolouration of teeth
• photosensitivity