| Aminoglycosides | Binds to 30S subunit causing misreading of mRNA | Nephrotoxicity, Ototoxicity | |
| Tetracyclines | Binds to 30S subunit blocking binding of aminoacyl-tRNA | Discolouration of teeth, photosensitivity | |
| Chloramphenicol | Binds to 50S subunit, inhibiting peptidyl transferase | Aplastic anaemia | |
| Clindamycin | Binds to 50S subunit, inhibiting translocation (movement of tRNA from acceptor site to peptidyl site) | Common cause of C. difficile diarrhoea | |
| Macrolides | Binds to 50S subunit, inhibiting translocation (movement of tRNA from acceptor site to peptidyl site) | Nausea (especially erythromycin), P450 inhibitor, prolonged QT interval | Commonly used for patients who are allergic to penicillin |