MRCEM Notes

Respiratory tract infections: NICE guidelines

NICE issued guidance in 2008 on the management of respiratory tract infection, focusing on the prescribing of antibiotics for self-limiting respiratory tract infections in adults and children in primary care

A no antibiotic prescribing or delayed antibiotic prescribing approach is generally recommended for patients with acute otitis media, acute sore throat/acute pharyngitis/acute tonsillitis, common cold, acute rhinosinusitis or acute cough/acute bronchitis.

However, an immediate antibiotic prescribing approach may be considered for:
  • children younger than 2 years with bilateral acute otitis media
  • children with otorrhoea who have acute otitis media
  • patients with acute sore throat/acute pharyngitis/acute tonsillitis when 3 or more Centor criteria are present

The Centor criteria* are as follows:
  • presence of tonsillar exudate
  • tender anterior cervical lymphadenopathy or lymphadenitis
  • history of fever
  • absence of cough

If the patient is deemed at risk of developing complications, an immediate antibiotic prescribing policy is recommended
  • are systemically very unwell
  • have symptoms and signs suggestive of serious illness and/or complications (particularly pneumonia, mastoiditis, peritonsillar abscess, peritonsillar cellulitis, intraorbital or intracranial complications)
  • are at high risk of serious complications because of pre-existing comorbidity. This includes patients with significant heart, lung, renal, liver or neuromuscular disease, immunosuppression, cystic fibrosis, and young children who were born prematurely
  • are older than 65 years with acute cough and two or more of the following, or older than 80 years with acute cough and one or more of the following:
  • - hospitalisation in previous year
  • - type 1 or type 2 diabetes
  • - history of congestive heart failure
  • - current use of oral glucocorticoids

The guidelines also suggest that patients should be advised how long respiratory tract infections may last:
  • acute otitis media: 4 days
  • acute sore throat/acute pharyngitis/acute tonsillitis: 1 week
  • common cold: 1 1/2 weeks
  • acute rhinosinusitis: 2 1/2 weeks
  • acute cough/acute bronchitis: 3 weeks

*if 3 or more of the criteria are present there is a 40-60% chance the sore throat is caused by Group A beta-haemolytic Streptococcus
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