MRCEM Notes

Premature ovarian failure

Premature ovarian failure is defined as the onset of menopausal symptoms and elevated gonadotrophin levels before the age of 40 years. It occurs in around 1 in 100 women.

Causes
  • idiopathic - the most common cause
  • chemotherapy
  • autoimmune
  • radiation

Features are similar to those of the normal climacteric but the actual presenting problem may differ
  • climacteric symptoms: hot flushes, night sweats
  • infertility
  • secondary amenorrhoea
  • raised FSH, LH levels
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