Cell surface proteins
The table below shows the most common cell surface proteins associated with particular cell types:
The table below lists the major clusters of differentiation (CD) molecules and describes their function.
| Type of cell | Cell surface markers |
|---|---|
| Haematopoietic stem cells | CD34 |
| Helper T cell | CD4, TCR, CD3, CD28 |
| Cytotoxic T cell | CD8, TCR, CD3, CD28 |
| Regulatory T cell | CD4, CD25, TCR, CD3, CD28 |
| B cell | CD19, CD20, CD40, MHC II, B7 |
| Macrophage | CD14, CD40, MHC II, B7 |
| Natural killer cell | CD16, CD56 |
The table below lists the major clusters of differentiation (CD) molecules and describes their function.
| Cluster of differentiation | Function |
|---|---|
| CD1 | MHC molecule that presents lipid molecules |
| CD2 | Found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion |
| CD3 | The signalling component of the T cell receptor (TCR) complex |
| CD4 | Found on helper T cells. Co-receptor for MHC class II Used by HIV to enter T cells |
| CD5 | Found in the majority of mantle cell lymphomas |
| CD8 | Found on cytotoxic T cells. Co-receptor for MHC class I Found on a subset of myeloid dendritic cells |
| CD14 | Cell surface marker for macrophages |
| CD15 | Expressed on Reed-Sternberg cells (along with CD30) |
| CD16 | Bind to the Fc portion of IgG antibodies |
| CD21 | Receptor for Epstein-Barr virus |
| CD28 | Interacts with B7 on antigen presenting cell as costimulation signal |
| CD45 | Protein tyrosine phosphatase present on all leucocytes |
| CD56 | Unique marker for natural killer cells |
| CD95 | Acts as the FAS receptor, involved in apoptosis |