MRCEM Notes

Antihistamines

Antihistamines (H1 inhibitors) are of value in the treatment of allergic rhinitis and urticaria.

Examples of sedating antihistamines
  • chlorpheniramine

As well as being sedating these antihistamines have some antimuscarinic properties (e.g. urinary retention, dry mouth).

Examples of non-sedating antihistamines
  • loratidine
  • cetirizine

Of the non-sedating antihistamines there is some evidence that cetirizine may cause more drowsiness than other drugs in the class.
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