MRCEM Notes

Opiate Toxidrome

A toxidrome refers to a set of symptoms and signs which occur following overdose of a particular class of drug. Commonly seen toxidromes are cholinergic, anticholingeric, sympathomimetic, opiate and sedative.

Opiate compounds, e.g. heroin, morphine and fentanyl, stimulate opiate receptors.


Key features of the opiate toxidrome:
  • Respiratory depression
  • Pin-point pupils
  • Hypotension
  • Drowsiness
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