MRCEM Notes

Antibiotics

Antibiotic ClassMode of Action
PenicillinsBeta-Lactam inhibit peptidoglycan cross-links in bacterial cell wall
CephalosporinsBeta-Lactam inhibit peptidoglycan cross-links in bacterial cell wall
MacrolidesPeptidyltransferase Inhibitor
QuinolonesDNA Gyrase Inhibitor
TetracyclinesBind to 30S subunit of microbial ribosomes blocking attachment of aminoacyl-tRNA to the A site on the ribosome
NitrofurantoinDamages bacterial DNA via multiple reactive intermediaries
TrimethoprimDihydrofolate Reductase Inhibitor
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