Cystic fibrosis
Cystic fibrosis (CF) is an autosomal recessive disorder causing increased viscosity of secretions (e.g. lungs and pancreas). It is due to a defect in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which codes a cAMP-regulated chloride channel
In the UK 80% of CF cases are due to delta F508 on the long arm of chromosome 7. Cystic fibrosis affects 1 per 2500 births, and the carrier rate is c. 1 in 25
Organisms which may colonise CF patients
*previously known as Pseudomonas cepacia
In the UK 80% of CF cases are due to delta F508 on the long arm of chromosome 7. Cystic fibrosis affects 1 per 2500 births, and the carrier rate is c. 1 in 25
Organisms which may colonise CF patients
- Staphylococcus aureus
- Pseudomonas aeruginosa
- Burkholderia cepacia*
- Aspergillus
*previously known as Pseudomonas cepacia