MRCEM Notes

Normal (Gaussian) distribution

The normal distribution is also known as the Gaussian distribution or 'bell-shaped' distribution. It describes the spread of many biological and clinical measurements

In a normal (Gaussian) distribution the median equals the mode and mean value. 68.2% of values are within 1 standard deviation of the mean, 95.4% are within 2 standard deviations of the mean and 99.7% are within 3 standard deviations of the mean. This is known as the three-sigma rule or empirical rule.

Gaussian distribution. Click on image to enalrge

Properties of the Normal distribution:
  • Symmetrical i.e. Mean = mode = median
  • 68.2% of values lie within 1 SD of the mean
  • 95.4% of values lie within 2 SD of the mean
  • 99.7% of values lie within 3 SD of the mean
  • This is often reversed, so that within 1.96 SD of the mean lie 95% of the sample values
  • The range of the mean - (1.96 *SD) to the mean + (1.96 * SD) is called the 95% confidence interval, i.e. If a repeat sample of 100 observations are taken from the same group 95 of them would be expected to lie in that range

Standard deviation:

  • the standard deviation (SD) is a measure of how much dispersion exists from the mean
  • SD = √ variance (square root of variance)
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