MRCEM Notes

Vitamin C (ascorbic acid)

Vitamin C is a water soluble vitamin.

Functions
  • antioxidant
  • collagen synthesis: acts as a cofactor for enzymes that are required for the hydroxylation proline and lysine in the synthesis of collagen
  • facilitates iron absorption
  • cofactor for norepinephrine synthesis

Vitamin C deficiency (scurvy) leads to defective synthesis of collagen resulting in capillary fragility (bleeding tendency) and poor wound healing

Features vitamin C deficiency
  • gingivitis, loose teeth
  • poor wound healing
  • bleeding from gums, haematuria, epistaxis
  • general malaise
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