MRCEM Notes

Focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis is cause of nephrotic syndrome and chronic kidney disease. It generally presents in young adults.

Causes
  • idiopathic
  • secondary to other renal pathology e.g. IgA nephropathy, reflux nephropathy
  • HIV
  • heroin
  • Alport's syndrome
  • sickle-cell

Focal segmental glomerulosclerosis is noted for having a high recurrence rate in renal transplants.

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Sclerosis of the glomerulus is seen next to Bowman's capsule

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Sclerosis is seen in the perihilar region of the glomerulus
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