Splenomegaly
Massive splenomegaly
Other causes (as above plus)
*the majority of adults patients with sickle-cell will have an atrophied spleen due to repeated infarction
- myelofibrosis
- chronic myeloid leukaemia
- visceral leishmaniasis (kala-azar)
- malaria
- Gaucher's syndrome
Other causes (as above plus)
- portal hypertension e.g. secondary to cirrhosis
- lymphoproliferative disease e.g. CLL, Hodgkin's
- haemolytic anaemia
- infection: hepatitis, glandular fever
- infective endocarditis
- sickle-cell*, thalassaemia
- rheumatoid arthritis (Felty's syndrome)
*the majority of adults patients with sickle-cell will have an atrophied spleen due to repeated infarction