MRCEM Notes

Erythema multiforme

Features
  • target lesions
  • initially seen on the back of the hands / feet before spreading to the torso
  • upper limbs are more commonly affected than the lower limbs
  • pruritus is occasionally seen and is usually mild

If symptoms are severe and involve blistering and mucosal involvement the term Stevens-Johnson syndrome is used.

Causes
  • viruses: herpes simplex virus (the most common cause), Orf*
  • idiopathic
  • bacteria: Mycoplasma, Streptococcus
  • drugs: penicillin, sulphonamides, carbamazepine, allopurinol, NSAIDs, oral contraceptive pill, nevirapine
  • connective tissue disease e.g. Systemic lupus erythematosus
  • sarcoidosis
  • malignancy

© Image used on license from DermNet NZ

© Image used on license from DermNet NZ

© Image used on license from DermNet NZ

© Image used on license from DermNet NZ


*Orf is a skin disease of sheep and goats caused by a parapox virus
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