Ciclosporin
Ciclosporin is an immunosuppressant which decreases clonal proliferation of T cells by reducing IL-2 release. It acts by binding to cyclophilin forming a complex which inhibits calcineurin, a phosphotase that activates various transcription factors in T cells
Adverse effects of ciclosporin (note how everything is increased - fluid, BP, K+, hair, gums, glucose)
Interestingly for an immunosuppressant, ciclosporin is noted by the BNF to be 'virtually non-myelotoxic'.
Indications
Adverse effects of ciclosporin (note how everything is increased - fluid, BP, K+, hair, gums, glucose)
- nephrotoxicity
- hepatotoxicity
- fluid retention
- hypertension
- hyperkalaemia
- hypertrichosis
- gingival hyperplasia
- tremor
- impaired glucose tolerance
- hyperlipidaemia
- increased susceptibility to severe infection
Interestingly for an immunosuppressant, ciclosporin is noted by the BNF to be 'virtually non-myelotoxic'.
Indications
- following organ transplantation
- rheumatoid arthritis
- psoriasis (has a direct effect on keratinocytes as well as modulating T cell function)
- ulcerative colitis
- pure red cell aplasia