MRCEM Notes

Prolactin

NotesFurther detail
SourceAnterior pituitary
FunctionStimulates breast development (both initially and further hyperplasia during pregnancy)
Stimulates milk productio

It decreases GnRH pulsatility at the hypothalamic level and to a lesser extent, blocks the action of LH on the ovary or testis.
RegulationProlactin secretion is under constant inhibition by dopamine

Increases secretion
  • thyrotropin releasing hormone
  • pregnancy
  • oestrogen
  • breastfeeding
  • sleep
  • stress
  • drugs e.g. metoclopramide, antipsychotics

Decreases secretion
  • dopamine
  • dopaminergic agonists
Full-size image