Metoclopramide
Metoclopramide is a D2 receptor antagonist mainly used in the management of nausea. Other uses include:
Adverse effects
- gastro-oesophageal reflux disease
- prokinetic action is useful in gastroparesis secondary to diabetic neuropathy
- often combined with analgesics for the treatment of migraine (migraine attacks result in gastroparesis, slowing the absorption of analgesics)
Adverse effects
- extrapyramidal effects: oculogyric crisis. This is particularly a problem in children and young adults
- hyperprolactinaemia
- tardive dyskinesia
- parkinsonism