Trimethoprim

Trimethoprim is an antibiotic, mainly used in the management of urinary tract infections.

Mechanism of action

• interferes with DNA synthesis by inhibiting dihydrofolate reductase

Adverse effects

• myelosuppression
• transient rise in creatinine: trimethoprim competitively inhibits the tubular secretion of creatinine resulting in a temporary increase which reverses upon stopping the drug