Serotonin Toxidrome
A toxidrome refers to a set of symptoms and signs which occur following overdose of a particular class of drug. Commonly seen toxidromes are cholinergic, anticholingeric, sympathomimetic, opiate, serotonin and sedative.
The serotonin toxidrome is sometimes referred to as serotonin syndrome.
Serotonin activity can be enhanced by many classes of drugs though antidepressants e.g. SSRIs/MAOIs are the most common.
The serotonin toxidrome can cause autonomic stimulation (hyperthermia, tachycardia, sweating, tremor, flushing and hypertension), changed mental state (anxiety, agitation, confusion) and neuromuscular excitation (clonus, hyperreflexia, myoclonus, rigidity).
The serotonin toxidrome is sometimes referred to as serotonin syndrome.
Serotonin activity can be enhanced by many classes of drugs though antidepressants e.g. SSRIs/MAOIs are the most common.
The serotonin toxidrome can cause autonomic stimulation (hyperthermia, tachycardia, sweating, tremor, flushing and hypertension), changed mental state (anxiety, agitation, confusion) and neuromuscular excitation (clonus, hyperreflexia, myoclonus, rigidity).